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Filtered Search Results
Medchemexpress LLC Dihydroergocristine mesylate | 24730-10-7 | 1 ML
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Dihydroergocristine mesylate (DHEC mesylate) is an inhibitor of γ-secretase (GSI) that effectively reduces the production of amyloid-β peptides associated with Alzheimer's disease. It directly binds to γ-secretase and Nicastrin, exhibiting high affinity. This product is for research use only.
- Inhibits γ-secretase activity in T100 cells without affecting cell viability
- Decreases cellular Aβ production
- Causes dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs)
- Reduces γ-secretase activity in fibroblast cells
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Medchemexpress LLC Ruboxistaurin mesylate | 192050-59-2 | 99.9% | 564.65 g/mol | C29H32N4O6S | 50 MG
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Ruboxistaurin mesylate is an orally active, selective, ATP-competitive protein kinase C beta (PKCβ) inhibitor used in preclinical research on diabetic complications, retinal disorders, and cardiovascular conditions. Supplied as the mesylate salt, it is an orange-to-red solid with molecular formula C29H32N4O6S and molecular weight 564.65 g/mol.
- Selective PKCβ inhibition with low nanomolar potency (IC50 ~4.7-5.9 nM).
- Mesylate salt form for improved stability and handling.
- High purity (99.87%) suitable for research applications.
- Orange-to-red solid, convenient for solid-state storage.
- Molecular formula C29H32N4O6S and molecular weight 564.65 g/mol.
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TARGETMOL CHEMICALS INC DABRAFENIB MESYLATE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf respectively). purity: 99%
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Medchemexpress LLC Almonertinib (mesylate) | 2134096-06-1 | 99.7% | 621.75 | 1 ML
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Almonertinib mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It shows high selectivity for EGFR-sensitizing and T790M resistance mutations, with inhibitory activity against T790M, T790M/L858R, and T790M/Del19. It is used for the research of non-small cell lung cancer (NSCLC). This compound can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available inhibitor
- Irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Inhibitory activity against T790M, T790M/L858R, and T790M/Del19
- Less effective against wild type EGFR
- Used for non-small cell lung cancer research
- Can inhibit other EGFR sensitive mutations like G719X, del19, L858R, and L861Q
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Medchemexpress LLC Dihydroergocristine mesylate | 24730-10-7 | MFCD00153792 | ≥98.0% | 707.84 | C36H45N5O8S | 10 MG
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Dihydroergocristine mesylate is a research reagent reported to act as a γ-secretase inhibitor; it reduces production of amyloid-β peptides and binds directly to γ-secretase and nicastrin. It is supplied as the mesylate salt for use in neuroscience and Alzheimer's disease research.
- Acts as a γ-secretase inhibitor.
- Reduces production of amyloid-β peptides.
- Binds directly to γ-secretase and nicastrin.
- Supplied as the mesylate salt.
- Available in small research quantities suitable for analytical or in-vitro studies.
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Aobchem 2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 1g
2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 1g
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Ambeed AMBEED
5000948929 5-METHYLQUINOLINE-3-CARBO 50MG
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Aobchem (3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 1g
(3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 1g
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Aobchem (4-Bromo-3-(morpholine-4-carbonyl)phenyl)boronic acid | 97% | C11H13BBrNO4 | 1g
(4-Bromo-3-(morpholine-4-carbonyl)phenyl)boronic acid | 97% | C11H13BBrNO4 | 1g
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Medchemexpress LLC Benzamide, 5-(3-azetidinylamino)-N-[(1R)-1-[3-[5-[[[(1S,3R)-3-hydroxycyclopentyl)amino]methyl]-2- | 2817811-16-6 | C29H36N4O2S | 200 MG
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XR8-89 is a potent papain-like protease (PLpro) inhibitor with an IC50 value of 0.1 μM. This compound induces conformational changes in SARS-CoV-2 papain-like protease, effectively inhibiting SARS-CoV-2 replication, making it suitable for research applications.
- Potent papain-like protease (PLpro) inhibitor
- IC50 value of 0.1 μM against papain-like protease
- Induces conformational changes in SARS-CoV-2 papain-like protease
- Inhibits SARS-CoV-2 replication
- For SARS-CoV-2 research use
- Purity of 97.13%
- Appears as a light yellow to yellow solid
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Apexbio Technology LLC Tasquinimod 254964-60-8 200mg
Tasquinimod (CAS 254964-60-8) is an orally bioavailable quinoline-3-carboxamide compound with antiangiogenic and antitumor properties It modulates angiogenesis primarily through dual inhibition of S100A9/TLR4 signaling in myeloid-derived suppressor cells (MDSCs) and downregulation of HIF-1 and VEGF expression in tumor and endothelial cells It also enhances thrombospondin-1 (TSP-1) expression further suppressing neovascularization Preclinical studies in human prostate cancer xenograft models indicate significant antineoplastic activity particularly in combination with docetaxel radiation therapy or androgen-depletion strategies suggesting its therapeutic potential for castration-resistant prostate cancer (CRPC)
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TARGETMOL CHEMICALS INC Rivastigmine 200MG
Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease. Purity 99.85%
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Medchemexpress LLC O-tert-Butyl-N-carbobenzoxy-L-serine methyl ester | 1872-59-9 | MFCD00037803 | 309.36 | 5 G
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O-tert-Butyl-N-carbobenzoxy-L-serine methyl ester is a serine derivative. Amino acids and amino acid derivatives have been commercially used as ergogenic supplements, influencing the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress-related tasks, and preventing exercise-induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances.
- Serine derivative.
- Beneficial as ergogenic dietary substances.
- Influences secretion of anabolic hormones.
- Supplies fuel during exercise.
- Improves mental performance during stress-related tasks.
- Prevents exercise-induced muscle damage.
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Apexbio Technology LLC TDZD-8 327036-89-5 200mg
TDZD-8 (CAS 327036-89-5) is a selective non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3 ) exhibiting an IC50 of 1 4 M In addition to GSK-3 TDZD-8 also inhibits protein kinase C isoforms PKC I and PKC with IC50 values of 1 4 M and 1 1 M respectively Cellular studies have demonstrated that TDZD-8 suppresses both GSK-3 and PKC activity leading to reduced photodynamic therapy-induced neuronal necrosis and glial cell apoptosis Furthermore TDZD-8 has been shown to exert anti-leukemic effects in primary human leukemia cell models possibly through dual inhibition of PKC and FLT3 highlighting its utility in studies related to neuroprotection and leukemia
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Medchemexpress LLC 10-Deacetylbaccatin III | 32981-86-5 | 99.79% | 544.59 | 200 MG
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10-Deacetylbaccatin III (Standard) is the analytical standard of 10-Deacetylbaccatin III, intended for research and analytical applications. It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Grade of analytical standard.
- Reference standard supplied assay.
- Commonly used in HPLC, GC, and MS research experiments.
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